Soluble TNF receptors as prognostic factors for mortality.
نویسندگان
چکیده
منابع مشابه
Increased concentrations of tumour necrosis factor (TNF) and soluble TNF receptors in biliary obstruction in mice; soluble TNF receptors as prognostic factors for mortality.
Systemic tumour necrosis factor (TNF) is present in jaundiced mice. Two soluble TNF receptors, sTNFr-P55 and sTNFr-P75 are reported to play a part in the natural defence against TNF. This study investigated the properties of circulating TNF and sTNFr in jaundiced mice. The data show that TNF in these mice is biologically inactive and that an increase of both sTNFr is seen (p < 0.001). Surgical ...
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BACKGROUND AND OBJECTIVES Thalidomide modulates the production of tumor necrosis factor (TNF-alpha). Soluble TNF receptors, TNFR p55 and TNFR p75, modify TNF-alpha activity. In this study, we explored the relation between soluble TNF receptors and outcome in patients with advanced multiple myeloma treated with thalidomide. DESIGN AND METHODS The levels of soluble TNF receptor p55 and p75 were...
متن کاملThe endogenous balance of soluble tumor necrosis factor receptors and tumor necrosis factor modulates cachexia and mortality in mice acutely infected with Trypanosoma cruzi.
To better understand the role of tumor necrosis factor (TNF) during Trypanosoma cruzi infection in BALB/c mice, we have investigated the kinetics of circulating tumor necrosis factor (TNF), soluble TNF receptor 1 (sTNR1), and sTNFR2 levels, as well as the interactions between such factors, in relation to parasitemia, cachexia, and mortality of acutely infected animals. Our data show that the pa...
متن کاملارتباط سطح سرمی تری‌گلیسیرید, لیپو پروتئین با دانسیته‌ی بالا, تومورنکروز فاکتور آلفا و رسپتورهای محلول آن با فعالیت بیماری لوپوس اریتماتوز سیستمیک
Background & Objective: Systemic lupus erythematosus (SLE) is a disease with life-threatening complications. Since evidence indicates that measurement of triglyceride (TG) and HDL levels and tumor necrosis α factor (TNF- α) and its types I and II soluble receptors plays a major role in evaluation of lupus activity, this study was conducted to investigate the relationship between the above menti...
متن کاملPlasma cytokine parameters and mortality in patients with chronic heart failure.
BACKGROUND Inflammatory immune activation is an important feature in chronic heart failure (CHF). Little is known about the prognostic importance of tumor necrosis factor-alpha (TNF-alpha), soluble TNF-receptor 1 and 2 (sTNF-R1/sTNF-R2), interleukin-6 (IL-6), and soluble CD14 receptors (sCD14) in CHF patients. METHODS AND RESULTS In 152 CHF patients (age 61+/-1 years, New York Heart Associati...
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عنوان ژورنال:
- Gut
دوره 40 4 شماره
صفحات -
تاریخ انتشار 1997